In Vitro Fertilization (IVF) Research Study

We’re looking for women ages 35–42 to participate in The PROGRESS Study.

The PROGRESS Study is an investigational study to determine if Progesterone-IBSA administered as an injection under the skin (subcutaneous) is safe and effective in supporting the implantation and early pregnancy following a frozen embryo transfer (FET).

About the Sponsor:

IBSA Group, the study Sponsor, is a multinational pharmaceutical company headquartered in Switzerland, operating in 90 countries around the globe (including US). IBSA is one of the major players worldwide in the field of Reproductive Medicine.

About the Study:

The hormone progesterone plays a vital role in early pregnancy. Our researchers are investigating an alternative way to administer progesterone with the aim to discover if subcutaneous (under-the-skin) injections are as safe and effective as the current approved medication Crinone®.

Crinone® is a progesterone gel that is administered vaginally and has been approved by the United States Food and Drug Administration, or FDA. The use of Progesterone-IBSA in this study is investigational. An investigational use is one that is not approved by FDA. However, Progesterone-IBSA is already approved and marketed in more than 30 countries worldwide.

The PROGRESS Trial is registered with clinicaltrials.gov, a website run by the National Institutes of Health (NIH) that provides information about clinical trials, and can be found at Clinical Trials NC NCT04549116.

You may be eligible for the study if you fall into one of the following two categories:

You are undergoing or plan to undergo an ovarian stimulation treatment to produce multiple oocytes (eggs) and are interested in preimplantation genetic testing for aneuploidy (PGT-A) of the embryos.

You have already undergone ovarian stimulation in the past and have a frozen euploid embryo and you qualify for a frozen embryo transfer (FET).

And meet the following criteria:

Age 35-42
Are planning a single frozen embryo transfer
Have regular menstrual cycles (24-38 days)
Do not have history of recurrent pregnancy loss (2 or more consecutive losses)
Have a BMI of <38 kg/m2

Compensation:

Newly qualified participants who join the study, while screening is still open, may receive the following:

The study drug (Progesterone-IBSA/Crinone®), other study medications (Ovidrel®), study-related procedures, and study visits will be provided at no charge to you or your insurance company.
IVF Cycle (if needed) at no cost. This includes ovarian stimulation, oocyte/egg retrieval and embryo biopsy. Additionally, up to $4,000 for ovarian stimulation medications will be covered from Alto Pharmacy.
Frozen embryo transfer (FET) at no cost.
Preimplantation genetic testing for aneuploidy (PGT-A) will be provided at no cost to you for all eligible embryos via Igenomix.
Additional incentives provided if you do not need a stimulation cycle because you already have a frozen euploid already available for FET.
Certain non-study-related costs may apply. If so, these will be discussed with your study doctor or site.

How to sign up

If you’re interested in participating in this study, please contact one of the participating doctors nearest you:

Arizona

Fertility Treatment Center
2155 E Conference Dr #115
Tempe, AZ 85284
480-831-2445
aellibee@ftcivf.com
fertilitytreatmentcenter.com

California

HRC Fertility
15503 Ventura Blvd #200
Encino, CA 91436
818-788-7288 ext 5224
ClinicaltrialsENC@havingbabies.com
www.havingbabies.com

Connecticut

Illume Fertility
761 Main Avenue Suite 200
Norwalk, CT 06851
203-290-6510
cshan@illumefertility.com
www.illumefertility.com

Delaware

Reproductive Associates of Delaware
4735 Ogletown-Stanton Road MAP 2, Suite 3217
Newark, DE 19713
302-602-8852
edavies@radfertility.com
www.radfertility.com

Florida

IVF Florida Reproductive Associates
3251 N. State Road 7, Suite 200
Margate, Florida 33063
Karina.Stroker@ivfflorida.com
www.ivfflorida.com

The IVF Center
5901 Brick Court
Winter Park FL 32792
Diana Luz Morillo
407-672-1106
diana@theivfcenter.com

Women’s Medical Research Group, LLC
2454 McMullen Booth Rd STE 609
Clearwater, FL 33759
727-724-9730
gaylec@xxresearch.com
www.xxresearch.com

Illinois

InVia Fertility Specialists, PLLP
1585 N. Barrington Road, Suite 406,
Doctor’s Building 2
Hoffman Estates, IL 60169
Julia Kotov
847-884-8884
jkotov@inviafertility.com

New Jersey

University Reproductive Associates, PC
214 Terrace Avenue
Hasbrouck Heights, NJ 07604
Vicky Boden
201-288-6330
vboden@uranj.com

North Carolina

Carolina Conceptions
2601 Lake Dr #301
Raleigh, NC 27607
919-782-5911 Ext: 107
ssequeira@carolinaconceptions.com
www.carolinaconceptions.com

REACH
1524 East Morehead Street
Charlotte, NC 28207
704-343-4444
callcenter@northcarolinafertility.com
www.northcarolinafertility.com

Ohio

Institute for Reproductive Health
3805 Edwards Road, Suite 450
Cincinnati, OH 45209
Olivia Rickels
513-924-5554
ofmueller@irhfertility.com

Reproductive Medicine Research
200 Albert Sabin Way, Hospital, RM 4028
Cincinnati, OH 45209
Research Team / Katie Smith
513-584-4100
researchforwomen@uchealth.com

Pennsylvania

Main Line Fertility
825 Old Lancaster Road
Suite 170
Bryn Mawr, PA 19010
484-380-4861
ashley.mcfadden@mainlinefertility.com
www.mainlinefertility.com

Shady Grove Fertility
735 Chesterbrook Blvd
Chesterbrook, Pennsylvania 19087
574-876-4660
lindsay.pittman@usfertility.com
www.shadygrovefertility.com/locations/pennsylvania/chesterbrook-fertility-center/

Texas

Care Fertility
1701 Park Pl Ave
Bedford, TX 76022
817-540-7072
jessicac@embryo.net
www.embryo.net

Center of Reproductive Medicine, LLC., Shady Grove Fertility
1015 W. Medical Center Blvd
Suite 2100
Webster, TX 77598
281-557-3084
maryanne.fisher@sgfertility.com
www.shadygrovefertility.com

Utah

Utah Fertility Center
7050 Union Park Ave., Ste. 500
Midvale, UT 84047
801-785-5100
coral.halterman@utahfertility.com
utahfertility.com